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2024.12.07Paper

Published paper on the structure of the RNA synthesis inclusion body of paramyxoviruses.

Published paper on the structure of the RNA synthesis inclusion body of paramyxoviruses.

Katoh et al. Science Advances.


Viral RNA synthesis in mononegaviruses takes place in a cytoplasmic membraneless organelle called the inclusion bodies (IBs). The IB of mumps virus is a liquid organelle formed by liquid-liquid phase separation, in which the viral nucleocapsid, phospho (P) protein and polymerase protein form a cage-like reticular structure. Furthermore, RNAs containing G-quadruplex motif sequences were found to play an important role in the formation of IBs.


https://www.science.org/doi/10.1126/sciadv.adr0359