Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
The Department of Microbiology
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Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
The Department of Microbiology

研究業績

* Corresponding author

2024年

  1. Tahara M, Okura T, Sato M, Takeda M*. Optical control of mononegavirus gene expression and replication. MIMB. in press. Link


2023

  1. Shirato K*, Suwa R, Nao N, Kawase M, Sugimoto S, Kume Y, Chishiki M, Ono T, Okabe H, Norito S, Hosoya M, Takeda M, Hashimoto K. Molecular epidemiology of human metapneumovirus before after COVID-19 in East Japan in 2017-2-22. Jpn J Infect Dis. in press
  2. Takeda M*. Cleavage activation of respiratory viruses – Half a century of history from Sendai virus to SARS-CoV-2. Jpn J Infect Dis. in press Link
  3. Shimazaki N*, Kuwahara T, Nishijima H, Nakamura K, Sato K, Murano K, Itamura S, Akahori Y, Takashita E, Kishida N, Arita T, Nakauchi M, Takeda M, Hasegawa H, Ryo A, Harada Y. Establishment of reference reagents for single-radial-immunodiffusion assay on the 2022/23 seasonal influenza vaccine in Japan and their quality validation. Jpn J Infect Dis. in press Link
  4. Takashita E, Fujisaki S, Morita H, Nagata S, Miura H, Nagashima M, Watanabe S, Takeda M, Kawaoka Y, Hasegawa H. SARS-CoV-2 Omicron variants show a lower propensity to acquire resistance to RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors than Delta variants. Antiviral Res. Link
  5. Fukuhara H, Yumoto K, Sako M, Kajikawa M, Ose T, Kawamura M, Yoda M, Chen S, Ito Y, Takeda S, Mwaba MH, Wang J, Hashiguchi T, Kamishikiryo J, Maita N, Kitatsuji C, Takeda M, Kuroki K, Maenaka K. Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination. Research Square (preprint) eLife (under review). Link
  6. Ono T, Hashimoto K*, Kume Y, Chishiki M, Okabe H, Sato M, Norito S, Aso J, Sada M, Mochizuki I, Mashiyama F, Ishibashi N, Suzuki S, Sakuma H, Suwa R, Kawase M, Takeda M, Shirato K, Kimura H, Hosoya M. Molecular diversity of human respiratory syncytial virus before and during the COVID-19 pandemic in two neighboring Japanese cities. Microbiol Spectr e0260622, 2023. Link
  7. Takahashi T, Akagawa M, Kimura R, Sada M, Shirai T, Okayama K, Hayashi Y, Kondo M, Takeda M, Ryo A, Kimura H*. Molecular evolutionary analyses of the fusion protein gene in human respirovirus 1. Virus Res 333:199142. Link
  8. Matsuzaki Y, Ohmiya S, Ota R, Kitai Y, Watanabe O, Kitaoka S, Kumaki S, Onuma R. Watanabe Y, Nagai Y, Kadowaki Y, Shimotai Y, Nishimura H. Epidemiologic, clinical, and genetic characteristics of influenza C virus infections among outpatients and inpatients in Sendai, Japan from 2006 to 2020. J Clin Virol 162:105429, 2023. Link
  9. Okura T*, Tahara M, Otsuki N, Sato M, Takeuchi K, Takeda M. Generation of a photo controllable recombinant bovine parainfluenza virus type 3. Microbiol Immunol 67:204-209, 2023. Link
  10. Someya K, Okemoto-Nakamura Y, Kurata T, Kanbayashi D, Saito N, Itamochi M, Otsuki N, Hanada K, Takeda M. Establishment of measles virus receptor-expressing Vero cells lacking functional poliovirus receptors. Microbiol Immunol Online ahead of print. Link
  11. Miyano S*, Vynnycky E, Pattamavone C, Ichimura Y, Mori Y, Nouanthong P, Phounphenghack K, Tengbriacheu C, Khamphaphongphane B, Franzel L, Yang TU, Raaijimarkers H, Komada K, Ota T, Funato M, Takeda M, Hachiya M. Comparison of population-based measles-rubella immunoglobulin G antibody prevalence between 2014 and 2019 in Lao People's Democratic Republic: Impacts of the national immunization program. Int J Inf Dis 129: 70-77, 2023 Link
  12. Bae C, Katoh H*, Wakata A, Sakata M, Kato F*, Takeda M. Demonstration of bacterium-free very rapid reverse genetics system using mumps virus. Microbiol Immunol 67:44-47, 2023. Link


2022

  1. Liu Y, Katoh H*, Sekizuka T, Bae C, Wakata A, Kato F, Sakata M, Yamaji T, Wang Z, Takeda M. SNARE protein USE1 is involved in the glycosylation and the expression of mumps virus fusion protein and important for viral propagation. PLOS Pathogens 18:e101949, 2022.
  2. Iwata-Yoshikawa N, Kakizaki M, Shiwa-Sudo N, Okura T, Tahara M, Fukushi S, Maeda K, Kawase M, Asanuma H, Tomita Y, Takayama I, Matsuyama S, Shirato K, Suzuki T, Nagata N*, Takeda M*. Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways. Nat Commun 13: 6100, 2022. Link
  3. Akagawa M, Shirai T, Sada M, Nagasawa N, Kondo M, Takeda M, Nagasawa K, Kimura R, Okayama K, Hayashi Y, Sugai T, Tsugawa T, Ishii H, Kawashima H, Katayama K, Ryo A, Kimura H*. Detailed molecular interactions between respiratory syncytial virus fusion protein and the TLR4/MD-2 complex in silico. Viruses 14:2382, 2022. Link
  4. Mori Y*, Sakata M, Sakai S, Okamoto T, Nakatsu Y, Taguwa S, Otsuki N, Maeda Y, Hanada K, Matsuura Y, Takeda M. Membrane sphingomyelin in host cells is essential for nucleocapsid penetration into the cytoplasm after hemifusion during rubella virus entry. mBio (published online)
  5. Seki F*, Takeda M. Novel and classical morbilliviruses: Current knowledge of three divergent morbillivirus groups. Microbiol Immunol (in press)
  6. Kidokoro M*, Yamaguchi T, Nariai E, Kodama H, Nakata K, Sano T, Gotou K, Kisu T, Maruyama T, Kuba Y, Sakata W, Higashi T, Kiyota N, Sakai T, Yahiro S, Nagita A, Watanabe K, Hirokawa C, Hamabata H, Fujii Y, Yamamoto M, Yokoi H, Sakamoto M, Saito H, Shibata C, Inada M, Fujitani M, Minagawa H, Ito M, Shima A, Murano K, Katoh H, Kato F, Takeda M, Suga S. Nationwide and long-term molecular epidemiologic studies of mumps viruses that circulated in Japan between 1986-2017. Front Microbiol (in press)
  7. Wakata A*, Katoh H, Kato F, Takeda M. Nucleolar protein Treacle is important for the efficient growth of mumps virus. J Virol (in press)
  8. Suwa R, Kume Y, Kawase M, Chishiki M, Ono T, Norito S, Sato K, Okamoto M, Kumaki S, Nagai Y, Hosoya M, Takeda M, Nishimura H, Hashimoto K, Shirato K*. Practical validation of United States Centers for Disease Control and Prevention assays for the detection of human respiratory syncytial virus in Pediatric Inpatients in Japan. Pathogens 11:754, 2022.
  9. Okura T, Shirato K, Kakizaki M, Sugimoto S, Matsuyama S, Tanaka T, Kume Y, Chishiki M, Ono T, Moriishi K, Sonoyama M, Hosoya M, Hashimoto K, Maenaka K, Takeda M*: Hydrophobic Alpha-Helical Short Peptides in Overlapping Reading Frames of the Coronavirus Genome. Pathogens 11:877, 2022.
  10. Takashita E, Yamayoshi S, Fukushi S, Suzuki T, Maeda K, Sakai-Tagawa Y, Ito M, Uraki R, Holfmann P, Watanabe S, Takeda M, Hasegawa H, Imai M, Kawaoka Y*: Efficacy of antiviral agents against the Omicron subvariant BA.2. N Engl J Med 386:1475-1477, 2022.
  11. Kanai M, Kamiya H*, Okuno H, Sunagawa T, Tanaka-Taya K, Matsui T, Oishi K, Kitajima H, Takeda M, Mori Y: Epidemiology of congenital rubella syndrome related to the 2012-2013 rubella epidemic in Japan. J Pediatric Infect Dis Sco doi: 10.1093/jpids/piac043. Online ahead of print.
  12. Egawa K, Kakizaki M, Kume Y, Suwa R, Kawase M, Ono T, Chishiki M, Okabe H, Norito S, Sato M, Sakuma H, Suzuki S, Hosoya M, Takeda M, Hashimoto K, Shirato K*: Nearly complete genome sequences of 12 types of human rhinoviruses isolated from pediatric inpatients in Fukushima, Japan. Microbiol Resour Announc 13:e0052922, 2022.
  13. Sugimoto S, Kume Y, Suwa R, Kawase M, Kakizaki M, Egawa K, Ono T, Chishiki M, Okabe H, Norito S, Sato M, Sakuma H, Suzuki S, Hosoya M, Takeda M, Hashimoto K, Shirato K*: Ten Nearly Complete Genome Sequences of Human Orthorubulavirus 4 Isolated from Pediatric Inpatients in Fukushima, Japan. Microbiol Resour Announc 9:e0041122, 2022.
  14. Saso W, Yamasaki M, Nakakita S, Fukushi S, Tsuchimoto K, Watanabe N, Sriwilaijaroen N, Kanie O, Muramatsu M, Takahashi Y, Matano T, Takeda M, Suzuki Y*, Watashi K*: Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2. PLOS Pathog 18:e1010590, 2022.
  15. Kume Y, Hashimoto K*, Chishiki M, Norito S, Suwa R, Ono T, Mochizuki I, Mashiyama F, Ishibashi N, Suzuki S, Sakuma H, Takahashi H, Takeda M, Shirato K, Hosoya M: Changes in virus detection in hospitalized children before and after the severe acute respiratory syndrome coronavirus 2 pandemic. Influenza Other Respir Viruses 2022 Apr 29. doi: 10.1111/irv.12995. Online ahead of print.
  16. Shirato K*, Kakizaki M, Tomita Y, Kawase M, Takeda M: Detection of the ORF1 gene is an indicator of the possible isolation of severe acute respiratory syndrome coronavirus-2. Pathogens 11:302, 2022.
  17. Takashita E, inoshita N, Yamayoshi S, Sakai-Tagawa Y, Fujisaki S, Ito M, Iwatsuki-Horimoto K, Halfmann P, Watanabe S, Maeda K, Imai M, Mitsuya H, Ohmagari N, Takeda M, Hasegawa H, Kawaoka Y*: Efficacy of antiviral agents against the SARS-CoV-2 Omicron BA.2 variant. N Engl J Med 386:1475-1477, 2022.
  18. Ichimura Y, Yamauchi M, Yoshida N, Miyano S, Komada K, Thandar MM, Tiwara S, Mita T, Hombhanje FW, Mori Y, Takeda M, Hachiya M*. (2022) Effectiveness of immunization activities on measles and rubella immunity among individuals in East Sepik, Papua New Guinea: A cross-sectional study. IJID Regions 3:84-88, 2022.
  19. Kitai Y, Sato K, Shirato K, Ohmiya S, Watanabe O, Kisu T, Ota R, Takeda M, Kawakami K, Nishimura H*: Variation in thermal stability among respiratory syncytial virus clinical isolates under non-freezing conditions. Viruses 14:679, 2022.
  20. Kume Y, Hashimoto K*, Shirato K, Norito S, Suwa R, Chishiki M, Ono T, Mashiyama F, Mochizuki I, Sato M, Ishibashi N, Suzuki S, Sakuma H, Takahashi H, Takeda M, Hosoya M: Epidemiological and clinical characteristics of infections with seasonal human coronavirus and respiratory syncytial virus in hospitalized children immediately before the coronavirus disease 2019 pandemic. J Infect Chemother 28:859-865, 2022.
  21. Kakizaki M, Kume Y, Suwa R, Kawase M, Ono T, Chishiki M, Norito S, Sato M, Sakuma H, Suzuki S, Hosoya M, Takeda M, Hashimoto K, Shirato K*: Thirteen nearly complete genome sequences of human bocavirus 1 isoated from pediatric inpatients in Fukushima, Japan. Microbiol Resour Announc 11:e0102721, 2022.
  22. Takashita E, Kinoshita N, Yamayoshi S, Sakai-Tagawa Y, Fujisaki S, Ito M, Iwatsuki-Horimoto K, Chiba S, Halfmann P, Nagai H, Saito M, Adachi E, Sullivan D, Pekosz A, Watanabe S, Maeda K, Imai M, Yotsuyanagi H, Mitsuya H, Ohmagari N, Takeda M, Hasegawa H, Kawaoka Y*: Efficacy of antibodies and antivirals against a SARS-CoV-2 omicron variant. N Engl J Med 386:995-998, 2022.
  23. Shirato K*, Matsuyama S, Takeda M: Less frequent sequence mismatches in variants of concern (VOCs) of SARS-CoV-2 in the real–time RT–PCR assays developed by the National Institute of Infectious Diseases, Japan. Jpn J Infect Dis 75:96-101, 2022.
  24. Takeda M*: Proteolytic activation of SARS-CoV-2 spike protein. Microbiol Immunol 66:15-23, 2022.


2021

  1. Kato F*, Nakatsu Y, Murano K, Wakata A, Kubota T, Hishiki T, Yamaji T, Kidokoro M, Katoh H, Takeda M. Antiviral activity of CD437 against mumps virus. Front Microbiol 12:751909, 2021.
  2. Shirato K*, Tomita Y, Katoh H, Yamada S, Fukushi S, Matsuyama S, Takeda M: Performance evaluation of real–time RT–PCR assays for detection of severe acute respiratory syndrome coronavirus–2 developed by the National Institute of Infectious Diseases, Japan. Jpn J Infect Dis 74:465-472,2021.
  3. Saito M, Tsukagoshi H, Sada M, Sunagawa S, Shirai T, Okayama K, Sugai T, Tsugawa T, Hayashi Y, Ryo A, Takeda M, Kawashima H, Saruki N, Kimura H*. Detailed evolutionary analyses of the F gene in the respiratory syncytial virus subgroup A. Viruses. 13:2525, 2021.
  4. Okemoto–Nakamura Y, Someya K, Yamaji T, Saito K, Takeda M, Hanada K*. Poliovirus–nonsusceptible Vero cell line for the World Health Organization global action plan. Sci Rep 11:6746, 2021.
  5. Yamamoto Y, Nakano S, Seki F, Shigeta Y, Ito S, Tokiwa H, Takeda M*: Computational analysis reveals a critical point mutation in the N–terminal region of the signaling lymphocytic activation molecule responsible for the cross–species infection with canine distemper virus. Molecules 26:1262, 2021.
  6. Tomita Y, Takeda M, Matsuyama S*. (2021) The anti–influenza virus drug favipiravir has little effect on replication of SARS-CoV-2 in cultured cells. Antimicrob Agents Chemother 65:e00020–21, 2021.
  7. Tomita Y, Matsuyama S, Fukuhara H, Maenaka K, Kataoka H, Hashiguchi T, Takeda M*: The physiological TMPRSS2 inhibitor HAI–2 alleviates SARS-CoV-2 infection. J Virol 95:e00434–21, 2021.
  8. Shionoya K, Yamasaki M, Iwanami S, Ito Y, Fukushi S, Ohashi H, Saso W, Tanaka T, Aoki S, Kuramochi K, Iwami S, Takahashi Y, Suzuki T, Muramatsu M, Takeda M, Wakita T, Watashi K*: Mefloquine, a potent anti–severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) drug as an entry inhibitor in vitro. Front Microbiol 12:651403, 2021.
  9. Ohashi H, Watashi K*, Saso W, Shionoya K, Iwanami S, Hirokawa T, Shirai T, Kanaya S, Ito Y, Kim KS, Nomura T, Suzuki T, Nishioka K, Ando S, Ejima K, Koizumi Y, Tanaka T, Aoki S, Kuramochi K, Suzuki T, Hashiguchi T, Maenaka K, Matano T, Muramatsu M, Saijo M, Aihara K, Iwami S, Takeda M, McKeating JA, Wakita T: Potential anti–COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment. iScience 24:102367, 2021.
  10. Ohashi H, Wang F, Stappenbeck F, Tsuchimoto K, Kobayashi C, Saso W, Kataoka M, Yamasaki M, Kuramochi K, Muramatsu M, Suzuki T, Sureau C, Takeda M, Wakita T, Parhami F, Watashi K*: Identification of anti–severe acute respiratory syndrome–related coronavirus 2 (SARS-CoV-2) Oxysterol derivatives in vitro. Int J Mol Sci 22:3163, 2021.
  11. Ikegame S, Hashiguchi T, Hung CT, Dobrindt K, Brennand KJ, Takeda M, Lee B*: Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes. Proc Natl Acad Sci U S A 118:e2026027118, 2021.


2020

  1. Okamaoto K, Shirato K*, Nao N, Saito S, Kageyama T, Hasegawa H, Suzuki T, Matsuyama S, Takeda M: An assessment of real–time RT–PCR kits for SARS-CoV-2 detection. Jpn J Infect Dis 73:366–368, 2020.
  2. Shirato K*, Nao N, Katano H, Takayama I, Saito S, Kato F, Katho H, Sakata M, Nakatsu Y, Mori Y, Kageyama T, Matsuyama S, Takeda M: Development of genetic diagnositic methods for novel coronavirus 2019 (nCoV–2019) in Japan. Jpn J Infect Dis 73:304–307, 2020.
  3. Shirato K*, Nao N, Matsuyama S, Takeda M, Kageyama T: An ultra–rapid real–time RT–PCR method using the PCR1100 to detect severe acute respiratory syndrome coronavirus–2. Jpn J Infect Dis 74:29–34, 2020.
  4. Seki F, Ohishi K, Maruyama T, Takeda M*: Phocine distemper virus uses phocine and other animal SLAMs as a receptor but not human SLAM. Microbiol Immunol 64:578–583, 2020.
  5. Kato F*, Matsuyama S, Kawase M, Hishiki T, Katoh H, Takeda M: Antiviral activities of mycophenolic acid and IMD–0354 against SARS-CoV-2. Microbiol Immunol 64:635–639, 2020.
  6. Uchino K, Miyoshi T, Mori Y, Komase K, Okayama F, Shibata Y, Yoshida H, Numata T, Takeda M, Tanaka T*: Comparison of virological and serological methods for laboratory confirmation of rubella. J Clin Virol 123:104257, 2020.
  7. Nao N*, Saikusa M, Sato K, Sekizuka T, Usuku S, Tanaka N, Nishimura H, Takeda M: Recent molecular evolution of human metapneumovirus (HMPV): Subdivision of HMPV A2b strains. Microorganisms 8:E1280, 2020.
  8. Yamamoto M, Kiso M, Sakai–Tagawa Y, Iwatsuki–Horimoto K, Imai M, Takeda M, Kinoshita N, Ohmagari N, Gohda J, Semba K, Matsuda Z, Kawaguchi Y, Kawaoka Y, Inoue JI*: The anticoagulant nafamostat potently inhibits SARS-CoV-2 S protein–mediated fusion in a cell fusion assay system and viral infection in vitro in a cell–type–dependent manner. Viruses 12:E629, 2020.
  9. Yamagishi T*, Ohnishi M, Matsunaga N, Kakimoto K, Kamiya H, Okamoto K, Suzuki M, Gu Y, Sakaguchi M, Tajima T, Takaya S, Ohmagari N, Takeda M, Matsuyama S, Shirato K, Nao N, Hasegawa H, Kageyama T, Takayama I, Saito S, Wada K, Fujita R, Saito H, Okinaka K, Griffith M, Parry AE, Barnetson B, Leonard J, Wakita T: Environmental sampling for severe acute respiratory syndrome coronavirus 2 during a COVID-19 outbreak on the Diamond Princess cruise ship. J Infect Dis 222:1098–1102, 2020.
  10. Seki F, Yamamoto Y, Fukuhara H, Ohishi K, Maruyama T, Maenaka K, Tokiwa H, Takeda M*: Measles virus hemagglutinin protein establishes a specific interaction with the extreme N–terminal region of human signaling lymphocytic activation molecule to enhance infection. Front Microbiol 11:1830, 2020.
  11. Imai M, Iwatsuki–Horimoto K, Hatta M, Loeber S, Halfmann PJ, Nakajima N, Watanabe T, Ujie M, Takahashi K, Ito M, Yamada S, Fan S, Chiba S, Kuroda M, Guan L, Takada K, Armbrust T, Balogh A, Furusawa Y, Okuda M, Ueki H, Yasuhara A, Sakai–Tagawa Y, Lopes TJS, Kiso M, Yamayoshi S, Kinoshita N, Ohmagari N, Hattori SI, Takeda M, Mitsuya H, Krammer F, Suzuki T, Kawaoka Y*: Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development. Proc Natl Acad Sci U S A 117:16587–16595, 2020.
  12. Matsuyama S*, Nao N, Shirato K, Kawase M, Saito S, Takayama I, Nagata N, Sekizuka T, Katoh H, Kato F, Sakata M, Tahara M, Kutsuna S, Ohmagari N, Kuroda M, Suzuki T, Kageyama T, Takeda M*: Enhanced isolation of SARS-CoV-2 by TMPRSS2–expressing cells. Proc Natl Acad Sci U S A 117:7001–7003, 2020.
  13. Hiramoto T, Tahara M, Liao J, Soda Y, Miura Y, Kurita R, Hamana H, Inoue K, Kohara H, Miyamoto S, Hijikata Y, Okano S, Yamaguchi Y, Oda Y, Ichiyanagi K, Toh H, Sasaki H, Kishi H, Ryo A, Muraguchi A, Takeda M*, Tani K*: Non–transmissible MV vector with segmented RNA genome establishes different types of iPSCs from hematopoietic cells. Mol Ther 28:129–141, 2020.
  14. Halfmann PJ, Hatta M, Chiba S, Maemura T, Fan S, Takeda M, Kinoshita N, Hattori SI, Sakai–Tagawa Y, Iwatsuki–Horimoto K, Imai M, Kawaoka Y*. (2020) Transmission of SARS-CoV-2 in domestic cats. N Engl J Med 383:592–594, 2020.
  15. de Swart RL*, Takeda M*: Editorial overview: Combating measles during a COVID-19 pandemic. Curr Opin Virol Apr;41:iii–vii. DOI: 10.1016/j.coviro.2020.08.008, 2020
  16. Takeda M*, Seki F, Yamamoto Y, Nao N, Tokiwa H: Animal morbilliviruses and their cross–species transmission potential. Curr Opin Virol 41:38–45, 2020.


2019年

  1. Okabayashi H, Komada K, Kidokoro M, Kitamura T, Miyano S, Ito T, Phounphenghak K, Pathammavong C, Murano K, Nagai M, Mori Y, Komase K, Xeuatvongsa A, Takeda M, Hachiya M*: Seroprevalence of mumps before the introduction of mumps–containig vaccine in Lao PDR: Results from a nationwide cross–sectional population–based survey. BMC Res Notes 12:155, 2019.
  2. Saikusa M*, Nao N, Kawakami C, Usuku S, Tanaka N, Tahara M, Takeda M, Okubo I: Predominant detection of the subgroup A2b human metapneumovirus strain with 111–nucleotide duplication in Yokohama City, Japan in 2018. Jpn J Infect Dis 72:350–352, 2019.
  3. Nao N, Sato K, Yamagishi Y, Tahara M, Nakatsu Y, Seki F, Katoh H, Ohnuma A, Shirogane Y, Hayashi M, Suzuki T, Kikuta H, Nishimura H, Takeda M*: Consensus and variations in cell line specificity among human metapneumovirus strains. PLOS ONE 14:e0215822, 2019.
  4. Vynnycky E*, Miyano S, Komase K, Mori Y, Takeda M, Kitamura T, Xeuatvongsa A, Hachiya M: Estimating the immunogenicity of measles–rubella vaccination administered during a mass campaign in Lao People's Democratic Republic using multi–valent seroprevalence data. Sci Rep 9:12545, 2019.
  5. Fukuhara H, Ito Y, Sako M, Yoshida K, Seki F, Hashiguchi T, Higashibata M, Ose T, Kuroki K, Takeda M, Maenaka K*: Specificity of morbillivirus hemagglutinins to recognize SLAM of different species. Viruses 11:E761, 2019.
  6. Iwata–Yoshikawa N, Okamura T, Shimizu Y, Kotani O, Sato H, Sekimukai H, Fukushi S, Suzuki T, Sato Y, Takeda M, Tashiro M, Hasegawa H, Nagata N*: Acute respiratory infection in human dipeptidyl peptidase 4–transgenic mice Infected with Middle East respiratory syndrome coronavirus. J Virol 93:e01818–18, 2019.
  7. Iwata–Yoshikawa N, Okamura T, Shimizu Y, Hasegawa H, Takeda M, Nagata N*: TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. J Virol 93:e01815–18, 2019.
  8. Sakata M*, Katoh H, Otsuki N, Okamoto K, Nakatsu Y, Lim CK, Saijo M, Takeda M, Mori Y: Heat shock protein 90 ensures the integrity of rubella virus p150 protein and supports viral replication. J Virol 93:e01142–19, 2019.
  9. Seki F, Miyoshi M, Ikeda T, Nishijima H, Saikusa M, Itamochi M, Minagawa H, Kurata T, Ootomo R, Kajiwara J, Kato T, Komase K, Tanaka–Taya K, Sunagawa T, Oishi K, Okabe N, Kimura H, Suga S, Kozawa K, Otsuki N, Mori Y, Shirabe K*, Takeda M*, Measles Surveillance Group in Japan, Technical Support Team for Measles Control in Japan: Nationwide molecular epidemiology of measles virus in Japan between 2008 and 2017. Front Microbiol 10:1470, 2019.
  10. Kimura H*, Shirabe K, Takeda M, Kobayashi M, Tsukagoshi H, Okayama K, Ryo A, Nagasawa K, Okabe N, Minagawa H, Kozawa K: The association between documentation of Koplik spots and laboratory diagnosis of measles and other rash diseases in a national measles surveillance program in Japan. Front Microbiol 10:269, 2019.
  11. Tadokoro T, Jahan ML, Ito Y, Tahara M, Chen S, Imai A, Sugimura N, Yoshida K, Saito M, Ose T, Hashiguchi T, Takeda M, Fukuhara H, Maenaka K*: Biophysical characterization and single–chain Fv construction of a neutralizing antibody to measles virus. FEBS J 287:145–159, 2019.
  12. Katoh H*, Sekizuka T, Nakatsu Y, Nakagawa R, Nao N, Sakata M, Kato F, Kuroda M, Kidokoro M, Takeda M: The R2TP complex regulates paramyxovirus RNA synthesis. PLOS Pathog 15:e1007749, 2019.
  13. Tahara M, Takishima Y, Miyamoto S, Nakatsu Y, Someya K, Sato M, Tani K, Takeda M*: Photocontrollable mononegaviruses. Proc Natl Acad Sci USA 116:11587–9, 2019.
  14. Brown KE*, Rota PA, Goodson JL, Williams D, Abernathy, Takeda M, Mulders MN: Genetic characterization of measles and rubella viruses detected through global measles and rubella elimination surveillance, 2016–2018. MMWR 68:587–591, 2019.
  15. Ohishi K*, Maruyama T, Seki F, Takeda M: Marine Morbilliviruses: The diversity and interaction with receptors. Viruses 11:606, 2019.


Before 2018

  1. Otsuki N, Sakata M, Saito K, Okamoto K, Mori Y, Hanada K*, Takeda M*: Both sphingomyelin and cholesterol in the host cell membrane are essential for rubella virus entry. J Virol 92:e01130–17, 2018.
  2. Saikusa M*, Kawakami C, Nao N, Takeda M, Usuku S, Sasao T, Nishimoto K, Toyozawa T: 180–nucleotide duplication in the G gene of human metapneumovirus A2b subgroup strains circulating in Yokohama city, Japan, since 2014. Front Microbiol 8:402, 2017.
  3. Mori Y*, Miyoshi M, Kikuchi M, Sekine M, Umezawa M, Saikusa M, Matsushima Y, Itamochi M, Yasui Y, Kanbayashi D, Miyoshi T, Akiyoshi K, Tatsumi C, Zaitsu S, Kadoguchi M, Otsuki N, Okamoto K, Sakata M, Komase K, Takeda M: Molecular epidemiology of rubella virus strains detected around the time of the 2012–2013 epidemic in Japan. Front Microbiol 8:1513, 2017.
  4. Katoh H*, Kubota T, Nakatsu Y, Tahara M, Kidokoro M, Takeda M: Heat shock protein 90 ensures efficient mumps virus replication by assisting with viral polymerase complex formation. J Virol 91:e02220–16, 2017.
  5. Rota P*, Moss WJ, Takeda M, de Swart RL, Thompson KM, Goodson JL: Measles. Nat Rev Dis Primers 2:16049, 2016.
  6. Mulders MN, Rota PA, Icenogle JP, Brown KE, Takeda M, Rey GJ, Mamou MCB, Dosseh ARGA, Byabamazima CR, Ahmed HJ, Pattamadilok S, Zhang Y, Gacic–Dobo M, Strebel PM, Goodson JL*: Global measles and rubella laboratory network support for elimination goals, 2010–2015. MMWR 65:438–42, 2016.
  7. Katoh H, Kubota T, Ihara T, Maeda K, Takeda M*, Kidokoro M: Cross–neutralization between human and African bat mumps viruses. Emerg Infect Dis 22:703–706, 2016.
  8. Yamaoka Y, Matsuyama S, Fukushi S, Matsunaga S, Matsushima Y, Kuroyama H, Kimura H, Takeda M, Chimuro T, Ryo A*: Development of monoclonal antibody and diagnostic test for Middle East respiratory syndrome coronavirus using cell–free synthesized nucleocapsid antigen. Front Microbiol 7:509, 2016.
  9. Yamamoto M, Matsuyama S, Li X, Takeda M, Kawaguchi Y, Inoue J*, Matsuda Z*: Identification of nafamostat as a potent inhibitor of Middle East respiratory syndrome (MERS) corona virus S–mediated membrane fusion using the split protein–based cell–cell fusion assay. Antimicrob Agents Chemother 60:6532–6539, 2016.
  10. Esumi M*, Ishibashi M, Yamaguchi H, Nakajima S, Tai Y, Kikuta S, Sugitani M, Takeyama T, Tahara M, Takeda M, Wakita T: Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection. Hepatology 61:437–446, 2015.
  11. Katoh H*, Kubota T, Kita S, Nakatsu Y, Aoki N, Mori Y, Maenaka K, Takeda M, Kidokoro M: Heat shock protein 70 regulates degradation of the mumps virus phosphoprotein via the ubiquitin–proteasome pathway. J Virol 89:3188–3199, 2015.
  12. Sakai K*, Sekizuka T, Ami Y, Nakajima N, Kitazawa M, Sato Y, Nakajima K, Anraku M, Kubota T, Komase K, Takehara K, Hasegawa H, Odagiri T, Tashiro M, Kuroda M, Takeda M: A mutant H3N2 influenza virus uses an alternative activation mechanism in TMPRSS2 knockout mice by loss of an oligosaccharide in the hemagglutinin stalk region. J Virol 89:5154–5158, 2015.
  13. Katoh H*, Nakatsu Y, Kubota T, Sakata M, Takeda M, Kidokoro M: Mumps virus is released from the apical surface of polarized epithelial cells and the release is facilitated by a Rab11–mediated transport system. J Virol 89:12026–12034, 2015.
  14. Sakai K, Ami Y, Tahara M, Kubota T, Anraku M, Abe M, Nakajima N, Sekizuka T, Shirato K, Suzaki Y, Ainai A, Nakatsu Y, Kanou K, Nakamura K, Suzuki T, Komase K, Nobusawa E, Maenaka K, Kuroda M, Hasegawa H, Kawaoka Y, Tashiro M, Takeda M*: The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses. J Virol 88:5608–5616, 2014.
  15. Sakata M, Otsuki N, Okamoto K, Anraku M, Nagai M, Takeda M, Mori Y*: Short self–interacting N–terminal region of rubella virus capsid protein is essential for cooperative actions of capsid and nonstructural p150 proteins. J Virol 88:11187–11198, 2014.
  16. Taya K, Satoh H, Arai S, Yamagishi T, Tahata Y, Nakashima K, Sugawara T, Ohkusa Y, Matsui T, Saito T, Kanou K, Shimada T, Kinoshita H, Yamashita K, Yasui Y, Tada Y, Mori Y, Takeda M, Sunagawa T, Oishi K, Strebel P, Schluter WW, Kamiya H, Reef SE*, Chu SY, Martin R: Nationwide rubella epidemic – Japan, 2013. MMWR 62:457–462, 2013.
  17. Takaki H*, Takeda M, Tahara M, Shingai M, Oshium H, Matsumoto N, Seya T*: MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I interferon production against measles virus in a mouse infection model. J Immunol 191:4740–4747, 2013.
  18. Tahara M*, Ito Y, Brindley M, Ma X, He J, Xu S, Fukuhara H, Sakai K, Komase K, Rota P, Plemper R, Maenaka K, Takeda M: Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein. J Virol 87:666–675, 2013.
  19. Sakai K, Nagata N, Ami Y, Seki F, Suzaki Y, Iwata–Yoshikawa N, Suzuki T, Fukushi S, Mizutani T, Yoshikawa T, Otsuki N, Kurane I, Komase K, Yamaguchi R, Hasegawa H, Saijo M, Takeda M, Morikawa S*: Lethal canine distemper virus outbreak in cynomolgus monkeys in Japan in 2008. J Virol 87:1105–1114, 2013.
  20. Tahara M*, Ohno S, Sakai K, Ito Y, Fukuhara H, Komase K, Brindley MA, Rota PA, Plemper RK, Maenaka K, Takeda M: The receptor–binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope. J Virol 87:3583–3586, 2013.
  21. Nakatsu Y*, Ma X, Seki F, Suzuki T, Iwasaki M, Yanagi Y, Komase K, Takeda M: Intracellular transport of the measles virus RNP complex is mediated by Rab11A–positive recycling endosomes and drives virus release from the apical membrane of polarized epithelial cells. J Virol 87:4683–4693, 2013.
  22. Sakai K, Yoshikawa T, Seki F, Fukushi S, Tahara M, Nagata N, Ami Y, Mizutani T, Kurane I, Yamaguchi R, Hasegawa H, Saijo M, Komase K, Morikawa S*, Takeda M*: Canine distemper virus associated with a lethal outbreak in monkeys readily adapts to use human receptors. J Virol 87:7170–7175, 2013.
  23. Ito M, Iwasaki M, Takeda M, Nakamura T, Yanagi Y*, Ohno S*: Measles virus non–structural C protein modulates viral RNA polymerase activity by interacting with a host protein SHCBP1. J Virol 87:9633–9642, 2013.
  24. Abe M, Tahara M. Sakai K, Yamaguchi H, Kanou K, Shirato K, Kawase M, Noda M, Kimura H, Matsuyama S, Fukuhara H, Mizita K, Maenaka K, Ami Y, Esumi M, Kato A, Takeda M*: TMPRSS2 is an activating protease for respiratory parainfluenza viruses. J Virol 87:11930–11935, 2013.
  25. Krumm SA, Takeda M, Plemper RK*: The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity. J Biol Chem 288:29943–29953, 2013.
  26. Brindley MA, Takeda M, Plattet P, Plemper R*: Triggering the measles virus membrane fusion machinery. Proc Natl Acad Sci USA 109:E3018–3027, 2012.
  27. Mitsuki YY, Terahara K, Shibusawa K, Yamamoto T, Tsuchiya T, Mizukoshi F, Ishige M, Okada S, Kobayashi K, Morikawa Y, Nakayama T, Takeda M, Yanagi Y, Tsunetsugu–Yokota Y*: HIV–1 infection ex vivo accelerates measles virus infection by upregulating signaling lymphocytic activation molecule (SLAM) in CD4+ T cells. J Virol 86:7227–7234, 2012.
  28. Pratakpiriya W, Seki F, Otsuki N, Sakai K, Fukuhara H, Katamoto H, Hirai T, Maenaka K, Techangamsuwan S, Lan NT, Takeda M, Yamaguchi R*: Nectin4 is an epithelial cell receptor for canine distemper virus and involved in the neurovirulence. J Virol 86:10207–10210, 2012.
  29. Seki F*, Yamada K, Nakatsu Y, Okamura K, Yanagi Y, Nakayama T, Komase K, Takeda M: The SI strain of measles virus derived from an SSPE patient possesses typical genome alterations and unique amino acid changes that modulate receptor specificity and reduce membrane fusion activity. J Virol 85:11871–11882, 2011.
  30. Rota PA*, Brown K, Mankertz A, Santibanez S, Shulga S, Muller CP, Hübschen JM, Siqueira M, Beirnes J, Ahmed H, Triki H, Al–Busaidy S, Dosseh A, Byabamazima C, Smit S, Akoua–Koffi C, Bwogi J, Bukenya H, Wairagkar N, Ramamurty N, Incomserb P, Pattamadilok S, Jee Y, Lim W, Xu W, Komase K, Takeda M, Tran T, Castillo–Solorzano C, Chenoweth P, Brown D, Mulders MN, Bellini WJ, Featherstone D: Global distribution of measles genotypes and measles molecular epidemiology. J Infect Dis 204:S514–S523, 2011.
  31. Bankamp B*, Takeda M, Zhang Y, Xu W, Rota PA: Genetic characterization of measles vaccine strains. J Infect Dis 204:S533–S548, 2011.
  32. Meng X, Nakamura T, Okazaki T, Inoue H, Takahashi A, Miyamoto S, Sakaguchi G, Eto M, Naito S, Takeda M, Yanagi Y, Tani K*: Enhanced antitumor effects of an engineered measles virus Edmonston strain expressing the wild–type N, P, L genes on human renal cell carcinoma. Mol Ther 18:544–551, 2010.
  33. Ikegame S, Takeda M, Ohno S, Nakatsu Y, Nakanishi Y, Yanagi Y*: RIG–I and MDA5 RNA helicases both contribute to the induction of interferon–alpha/beta in measles virus–infected human cells. J Virol 84:372–379, 2010.
  34. Ayata M*, Takeuchi K, Takeda M, Ohgimoto S, Kato S, Sharma LB, Tanaka M, Kuwamura M, Ishida H, Ogura H: The F gene of the Osaka–2 strain of measles virus derived from a case of subacute sclerosing panencephalitis is a major determinant of neurovirulence. J Virol 84:11189–11199, 2010.
  35. Matsuyama S*, Nagata N, Shirato, K, Kawase M, Takeda M, Taguchi F: Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2. J Virol 84:12658–12664, 2010.
  36. Shirogane Y*, Takeda M, Tahara M, Ikegame S, Nakamura T, Yanagi Y: Epithelial–mesenchymal transition abolishes the susceptibility of polarized epithelial cell lines to measles virus. J Biol Chem 27:20882–20890, 2010.
  37. Yasukawa K, Oshiumi H, Takeda M, Ishihara N, Yanagi Y, Seya T, Kawabata S, Koshiba T*: Mitofusin 2 inhibits mitochondrial antiviral signaling. Sci Signal 2:ra47, 2009.
  38. Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS, Takeda M, Bugge TH, Kim S, Park Y, Marzi A, Pöhlmann S*: Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol 83:3200–3211, 2009.
  39. Iwasaki M, Takeda M, Shirogane Y, Nakatsu Y, Nakamura T, Yanagi Y*: The matrix protein of measles virus regulates viral RNA synthesis and assembly by interacting with the nucleocapsid protein. J Virol 83:10374–10383, 2009.
  40. Nakatsu Y, Takeda M*, Iwasaki M, Yanagi Y: A highly attenuated measles virus vaccine strain encodes a fully functional C protein. J Virol 83:11996–12001, 2009.
  41. Yanagi Y*, Takeda M, Ohno S, Hashiguchi T: Measles virus receptors. Curr Top Microbiol Immunol 329:13–30, 2009.
  42. Tahara M, Takeda M*, Shirogane Y, Hashiguchi T, Ohno S, Yanagi Y: Measles virus infects both polarized epithelial and immune cells using distinctive receptor–binding sites on its hemagglutinin. J Virol 82:4630–4637, 2008.
  43. Nakatsu Y, Takeda M*, Ohno S, Shirogane Y, Iwasaki M, Yanagi Y: Measles virus circumvents the host interferon response by different actions of the C and V proteins. J Virol 82:8296–8306, 2008.
  44. Shirogane Y, Takeda M*, Iwasaki M, Ishiguro N, Takeuchi H, Nakatsu Y, Tahara M, Kikuta H, Yanagi Y: Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2. J Virol 82:8942–8946, 2008.
  45. Takeda M*, Ohno S, Tahara M, Takeuchi H, Shirogane Y, Ohmura H, Nakamura T, Yanagi Y: Measles virus possessing the polymerase protein genes of the Edmonston vaccine strain exhibit attenuated gene expression and growth in cultured cells and SLAM–knockin mice. J Virol 82:11979–11984, 2008.
  46. 46.       Takeda M*: Measles virus breaks through epithelial cell barriers to achieve transmission. J Clin Invest 118:2386–2389, 2008.
  47. Hashiguchi T, Kajikawa M, Maita N, Takeda M, Kuroki K, Sasaki K, Kohda D, Yanagi Y*, Maenaka K*: Crystal structure of measles virus hemagglutinin provides insight into effective vaccines. Proc Natl Acad Sci U S A 104:19535–19540, 2007.
  48. Ohno S*, Ono N, Seki F, Takeda M, Kura S, Tsuzuki T, Yanagi Y: Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection. J Virol 81:1650–1659, 2007.
  49. Tahara M, Takeda M*, Seki F, Hashiguchi T, Yanagi Y: Multiple amino acid substitutions in hemagglutinin are necessary for wild–type measles virus to acquire the ability to use receptor CD46 efficiently. J Virol 81:2564–2572, 2007.
  50. Tahara M, Takeda M*, Yanagi Y: Altered interaction of the matrix protein with the cytoplasmic tail of hemagglutinin modulates measles virus growth by affecting virus assembly and cell–cell fusion. J Virol 81: 6827–6836, 2007.
  51. Takeda M*, Tahara M, Hashiguchi T, Sato TA, Jinnouchi F, Ueki S, Ohno S, Yanagi Y: A human lung carcinoma cell line supports efficient measles virus growth and syncytium formation via SLAM– and CD46–independent mechanism. J Virol 81:12091–12096, 2007.
  52. Takeda M*, Nakatsu Y, Ohno S, Seki F, Tahara M, Hashiguchi T, Yanagi Y: Generation of measles virus having segmented RNA genome. J Virol 80:4242–4248, 2006.
  53. Nakatsu Y, Takeda M*, Ohno S, Koga R, Yanagi Y: Translational inhibition and increased interferon induction in cells infected with a C protein–deficient measles virus. J Virol 80:11861–11867, 2006.
  54. Takeuchi K*, Takeda M, Miyajima N, Ami Y, Nagata N, Suzaki Y, Jamila S, Kadota S, Nagata K: Stringent requirement of the C protein of wild–type measles virus for growth both in vitro and in macaque. J Virol 79:7838–7844, 2005.
  55. Chen B, Takeda M, Lamb RA*: Influenza virus hemagglutinin (H3 subtype) requires palmitoylation of its cytoplasmic tail for assembly: M1 proteins of two subtypes differ in their ability to support assembly. J Virol 79:13673–13684, 2005.
  56. Takeda M*, Ohno S, Seki F, Nakatsu, Y, Tahara M, Yanagi Y: Long untranslated regions of the measles virus M and F genes control virus replication and cytopathogenicity. J Virol 79:14346–14354, 2005.
  57. Tahara M, Takeda M*, Yanagi Y: Contribution of matrix and large protein genes of the measles virus Edmonston strain to growth in cultured cells as revealed by recombinant viruses. J Virol 79:15218–15225, 2005.
  58. Takeda M, Leser GP, Russell CJ, Lamb RA*: Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion. Proc Natl Acad Sci USA 100:14610–14617, 2003.
  59. Mould JA, Paterson RG, Takeda M, Ohigashi Y, Venkataraman P, Lamb RA*, Pinto LH: Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes. Dev Cell 5:175–184, 2003.
  60. Takeda M, Pekosz A, Shuck K, Pinto LH, Lamb RA*: Influenza A virus M2 ion channel activity is essential for efficient replication in tissue culture. J Virol 76:1391–1399, 2002.
  61. Takeuchi K*, Takeda M, Miyajima N, Kobune F, Tanabayashi K, Tashiro M: Recombinant wild–type and Edmonston strain measles viruses bearing heterologous H proteins: Role of H protein in cell fusion and host cell specificity. J Virol 76:4891–4900, 2002.
  62. Hashimoto K, Ono N, Tatsuo H, Minagawa H, Takeda M, Takeuchi K, Yanagi Y*: SLAM (CD150)–independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein. J Virol 76:6743–6749, 2002.
  63. Lamb RA*, Takeda M: Death by influenza virus protein. Nat Med 7:1286–1288, 2001.
  64. Takeda M, Takeuchi K*, Miyajima N, Kobune F, Ami Y, Nagata N, Suzaki Y, Nagai Y, Tashiro M: Recovery of pathogenic measles virus from cloned cDNA. J Virol 74:6643–6647, 2000.
  65. Takeda M, Kato A, Kobune F, Sakata H, Li Y, Shioda T, Sakai Y, Asakawa M, Nagai Y*: Measles virus attenuation associated with transcriptional impediment and a few amino acid changes in the polymerase and accessory proteins. J Virol 72:8690–8696, 1998.


Lecture Movies etc

  1. Takeda M. Mock Lecture "On Coronaviruses" The University of Tokyo Open Campus 2023  August 2, 2023    Movie in Japanese
  2. Takeda M. Characteristics of novel coronavirus SARS-CoV-2, emergence of mutant viruses. 7th Biosafety Symposium,  September 16, 2021    Movie in Japanese
  3. Takeda M. Novel Coronavirus from the Evidence 185th Rokuryo Talk Relay Osaka, Japan.  October 3, 2020    Movie in Japanese
  4. Successful Isolation of the novel coronavirus in Japan, NIID  Press Conference, THE PAGE January 31, 2020    Movie in Japanese

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