We aim to identify host factors involved in the intracellular replication of paramyxoviruses, including mumps virus and Nipah virus, and to elucidate the mechanisms of paramyxovirus RNA synthesis and virion assembly by analyzing the interactions between these host factors and viral components. To date, we have clarified the mechanisms underlying the formation of viral inclusion bodies in infected cells, the relationships between the viral RNA polymerase and cellular chaperone proteins such as Hsp70 and Hsp90, and the involvement of SNARE proteins in the glycosylation of viral glycoproteins. In addition, we are currently investigating a variety of other host factors.

Main Related Publications

1. Yasukochi M, Hosogi M, Kitai Y, Akahori Y, Ryo A, Takeda M, Katoh H. Coordinated interactions among Nipah virus N, P, and M proteins drive formation of distinct inclusion bodies. J Gen Virol. Accepted.
2. Okura T, Nakai Y, Kameya T, Mizukoshi F, Okura H, Kakizaki M, Kato F, Matsumoto Y, Nakatsu Y, Takeuchi K, Kimura H, Takeda M, Otsuki N, Hasegawa H, Shirato K, Ryo A. Paramyxovirus matrix protein redirects METTL3 to modulate m6A epitranscriptomics and host innate immune response. PLOS Pathogens. Published.
3. Katoh H, Kimura R, Sekizuka T, Matsuoka K, Hosogi M, Kitai Y, Akahori Y, Kato F, Kataoka M, Kobayashi H, Nagata N, Suzuki T, Ohkawa Y, Oki S, Takeda M. Structural and molecular properties of mumps virus inclusion bodies. Sci Adv. 2024 Dec 6;10(49):eadr0359. doi: 10.1126/sciadv.adr0359. Epub 2024 Dec 6. PMID: 39642233; PMCID: PMC11623304.
4. Liu Y, Katoh H, Sekizuka T, Bae C, Wakata A, Kato F, Sakata M, Yamaji T, Wang Z, Takeda M. SNARE protein USE1 is involved in the glycosylation and the expression of mumps virus fusion protein and important for viral propagation. PLoS Pathog. 2022 Dec 8;18(12):e1010949. doi: 10.1371/journal.ppat.1010949. PMID: 36480520; PMCID: PMC9731409.
5. Wakata A, Katoh H, Kato F, Takeda M. Nucleolar Protein Treacle Is Important for the Efficient Growth of Mumps Virus. J Virol. 2022 Oct 12;96(19):e0072222. doi: 10.1128/jvi.00722-22. Epub 2022 Sep 22. PMID: 36135364; PMCID: PMC9555161.
6. Katoh H, Sekizuka T, Nakatsu Y, Nakagawa R, Nao N, Sakata M, Kato F, Kuroda M, Kidokoro M, Takeda M. The R2TP complex regulates paramyxovirus RNA synthesis. PLoS Pathog. 2019 May 23;15(5):e1007749. doi: 10.1371/journal.ppat.1007749. PMID: 31121004; PMCID: PMC6532945.
7. Katoh H, Kubota T, Nakatsu Y, Tahara M, Kidokoro M, Takeda M. Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation. J Virol. 2017 Feb 28;91(6):e02220-16. doi: 10.1128/JVI.02220-16. PMID: 28053100; PMCID: PMC5331814.
8. Katoh H, Kubota T, Kita S, Nakatsu Y, Aoki N, Mori Y, Maenaka K, Takeda M, Kidokoro M. Heat shock protein 70 regulates degradation of the mumps virus phosphoprotein via the ubiquitin-proteasome pathway. J Virol. 2015 Mar;89(6):3188-99. doi: 10.1128/JVI.03343-14. Epub 2014 Dec 31. PMID: 25552722; PMCID: PMC4337538.