Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
The Department of Microbiology
日本語
|
English
Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
The Department of Microbiology

Research

  • Research
  • Mechanisms of paramyxovirus replication - Interactions with host factors.

Mechanisms of paramyxovirus replication - Interactions with host factors.

We aim to elucidate the mechanisms of RNA synthesis and particle formation in paramyxoviruses, such as the mumps virus, by identifying host factors involved in their intracellular replication and analyzing their interactions with viral factors. So far, we have clarified the relationship between the mumps virus RNA polymerase and chaperone proteins (Hsp70 and Hsp90), as well as the involvement of SNARE proteins in the glycosylation of viral glycoproteins. Additionally, we are currently analyzing various other host factors.


Main Related Publications

  1. Yasukochi M, Hosogi M, Kitai Y, Akahori Y, Ryo A, Takeda M, Katoh H. Coordinated interactions among Nipah virus N, P, and M proteins drive formation of distinct inclusion bodies. J Gen Virol. Accepted.
  2. Okura T, Nakai Y, Kameya T, Mizukoshi F, Okura H, Kakizaki M, Kato F, Matsumoto Y, Nakatsu Y, Takeuchi K, Kimura H, Takeda M, Otsuki N, Hasegawa H, Shirato K, Ryo A. Paramyxovirus matrix protein redirects METTL3 to modulate m6A epitranscriptomics and host innate immune response. PLOS Pathogens. Published.
  3. Katoh H, Kimura R, Sekizuka T, Matsuoka K, Hosogi M, Kitai Y, Akahori Y, Kato F, Kataoka M, Kobayashi H, Nagata N, Suzuki T, Ohkawa Y, Oki S, Takeda M. Structural and molecular properties of mumps virus inclusion bodies. Sci Adv. 2024 Dec 6;10(49):eadr0359. doi: 10.1126/sciadv.adr0359. Epub 2024 Dec 6. PMID: 39642233; PMCID: PMC11623304.
  4. Liu Y, Katoh H, Sekizuka T, Bae C, Wakata A, Kato F, Sakata M, Yamaji T, Wang Z, Takeda M. SNARE protein USE1 is involved in the glycosylation and the expression of mumps virus fusion protein and important for viral propagation. PLoS Pathog. 2022 Dec 8;18(12):e1010949. doi: 10.1371/journal.ppat.1010949. PMID: 36480520; PMCID: PMC9731409.
  5. Wakata A, Katoh H, Kato F, Takeda M. Nucleolar Protein Treacle Is Important for the Efficient Growth of Mumps Virus. J Virol. 2022 Oct 12;96(19):e0072222. doi: 10.1128/jvi.00722-22. Epub 2022 Sep 22. PMID: 36135364; PMCID: PMC9555161.
  6. Katoh H, Sekizuka T, Nakatsu Y, Nakagawa R, Nao N, Sakata M, Kato F, Kuroda M, Kidokoro M, Takeda M. The R2TP complex regulates paramyxovirus RNA synthesis. PLoS Pathog. 2019 May 23;15(5):e1007749. doi: 10.1371/journal.ppat.1007749. PMID: 31121004; PMCID: PMC6532945.
  7. Katoh H, Kubota T, Nakatsu Y, Tahara M, Kidokoro M, Takeda M. Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation. J Virol. 2017 Feb 28;91(6):e02220-16. doi: 10.1128/JVI.02220-16. PMID: 28053100; PMCID: PMC5331814.
  8. Katoh H, Kubota T, Kita S, Nakatsu Y, Aoki N, Mori Y, Maenaka K, Takeda M, Kidokoro M. Heat shock protein 70 regulates degradation of the mumps virus phosphoprotein via the ubiquitin-proteasome pathway. J Virol. 2015 Mar;89(6):3188-99. doi: 10.1128/JVI.03343-14. Epub 2014 Dec 31. PMID: 25552722; PMCID: PMC4337538.