Research
Mechanisms of paramyxovirus replication - Interactions with host factors.
We study disease-causing mechanisms by searching for host factors required for paramyxoviruses such as mumps virus to multiply in cells and by clarifying their interactions with factors on the viral side.
Mechanism of Activation of Respiratory Viruses by Host Proteases
Many viruses have protein spikes (spike proteins) on the surface of their particles. We have shown that the spike proteins of various respiratory viruses are activated by a protease called TMPRSS2 in host cells.
Development and applied research on paramyxovirus vectors (e.g. development of nipah virus vaccines, development of vectors for regenerative medicine and cancer therapy)
Paramyxoviruses are used as viral vectors for gene therapy, cancer therapy, and vaccine development. We are conducting research on the development of various viral vectors for clinical applications.We are willing to accept collaborations and other research projects.
Studies on the host range of morbilliviruses.
Measles virus is a morbillivirus that infects humans. Other morbilliviruses that infect specific animal species (e.g. cattle, sheep, dogs, cats, dolphins and bats) also exist. We are studying how the host range of these morbilliviruses is determined.
Research on influenza viruses, RS virus and human metapneumovirus.
Influenza virus, respiratory syncytial virus (RSV), and human metapneumovirus are important respiratory pathogens. In addition to paramyxoviruses, we are conducting research aimed at elucidating the mechanisms of replication and pathogenicity of these respiratory viruses at the molecular level.
Basic and applied research on live attenuated measles vaccines.
Measles vaccines used are live-attenuated vaccines. We are conducting research on the mechanism of attenuation through laboratory passages of measles virus and on the characteristics of live vaccine strains, both of which are essential for vaccine development. Currently, we are also aiming to develop a Nipah virus vaccine using a recombinant live-attenuated measles vaccine.
Research on coronaviruses
We were deeply involved in the laboratory diagnosis of Japan’s first COVID-19 case, the development of diagnostic methods, the establishment of virus isolation techniques, and the development of therapeutic agents. To prepare for the next pandemic, we are continuing our research on coronaviruses.